Poor mitochondrial function leads to saturation of lactate clearance capacity at lower power outputs, forcing more lactate export into the blood.

“the first thing that stands out to me and we're going to talk about this later so I'll put a little pin in this is that the people with Metabolic Syndrome have a resting lactate that's almost 2 Millo yeah yes we see we see already this and it's a it's I think that it's going to become more and more as a biomarker like like resting BL glucose levels yes what what is your resting lactate and I you can see already in patients with type two diabetes or profound metabolic syndrome that yeah I you say perfectly yeah resting levels are you know in the neighborhood of like a 1 point8 1.5 to even three right”

“when you have a poorer mandal function uh it's going to get to a point that that capacity is going to get saturated at a lower power output and therefore you're going to be forced to export that to the blood”