Paul Saladino· MD
the neutrophil lymphocyte ratios of diabetic patients were significantly higher than those of healthy controls what does this lead to this leads to activation of the nlrp3 inflammasome and that is at the center of gout the nlrp3 inflamosome role in metabolic disorders and regulation by metabolic pathways what pathway did we see beta hydroxybutyrate improving what pathway do we see worsening when people are metabolically broken nlrp3 inflammasome this is the spark to the uric acid this is how metabolic dysfunction connects immunologically with increased levels of uric acid in those with gout so i looked for a connection here lo and behold monocytes and lymphocyte ratio neutrophil the lymphocyte ratio rdw are the associates with gaudy arthritis imagine that you guys a disorder neutrophil lymphocyte ratio associates with gaudy arthritis because metabolic dysfunction is driving this not purely uric acid in and of itself and as we've seen getting more uric acid in your diet or at least getting more purines doesn't lead to more uric acids how do you get gout you eat things that create uric acid while you have metabolic dysfunction if you eat things that create uric acid and you don't have metabolic dysfunction what happens you thrive nothing happens the hadza me kurt people on carnivore carnivorous diets fructose doesn't cod this unless it's in massive excess but linoleic acid just might be hydroxy octadeca and dienoic acids these are the hodes oxlam's novel regulators of macrophage differentiation and atherogenesis now the hypothesis here would be that excess oxidative products of linoleic acid metabolism are contributing to some of the innate immune system activation which leads to disordered immune response to underlying normal physiology like uric acid levels when we eat purines so if you want to avoid gout be metabolically healthy be metabolically healthy you don't have