Paul Saladino· MD
at the center of metabolic dysfunction at the center of chronic disease are fat cells that are hypertrophic rather than hyperplastic meaning fat cells that are too big yes
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at the center of metabolic dysfunction at the center of chronic disease are fat cells that are hypertrophic rather than hyperplastic meaning fat cells that are too big yes
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It's just that that visceral cavity is so limited in volume that it only allows fat growth through hypertrophy because that is a way to limit the total amount of fat you can grow. If our visceral fat was able to grow through hyperlasia, then it may expand so much that it starts to compress our our tissues. It starts to squeeze the liver or squeeze the intestines or squeeze the kidneys. And so by only allowing visceral fat to grow through hypertrophy, you do limit how much it can grow, but it also becomes much more pro-inflammatory because hypertrophic fat cells release a lot more pro-inflammatory cytoines than smaller hyperlastic fat cells.