Rhonda Patrick· PhD
That's a good point. So, one of the criticisms of the ketogenic diet was that it inhibits the pyruvate dehydrogenase complex. So, whenever we're doing carbohydrate restriction, we're limiting glucose availability but also lowering insulin. And by lowering insulin especially, that inhibits glycolytic enzymes like hexokinase. The transporter for glucose gets internalized into the cell if...you know, the glycolytic flux is essentially decreased.