Very large adipocytes exhibit increased basal lipolysis and amplified response to lipolytic signals, leading to reduced suppression of free fatty acids by insulin.

“so very very big adipocytes will have increased basal hypolysis and any lipolytic signal will be amplified and in a healthy metabolism if you um if you infuse insulin then theoretically what happens is that the cells let's say your muscle cells in your arms should uptake fatty acids and glucose but in fact as you suppress fatty acid released from adipocytes um then the total amount of fatty acids that are translocated by cd-36 actually goes down”