When the aldose reductase enzyme is induced, less glucose may be needed to trigger significant fat gain, fatty liver, and insulin resistance.

“you probably don't have to give a lot what about fat what if you did that same experiment with rats or mice which would be hard because to eat pure fat is difficult but if there was a way that somehow you could make it palatable enough that they could you could over feed them to the same extent using fat and protein let's say they're getting a normal amount of glucose but the over feed was coming through the fat would that induce any of these properties in other words is part of this due to an absolute sense of total energy being too high or is this really about a particular carbohydrate it's definitely about a particular carbohydrate”