Paul Saladino· MD
The most compelling evidence points to metabolic dysfunction arising at the level of fat cells (adipocytes), which become overdistended. How did these adipocytes get so full? Excess dietary linoleic acid.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
The most compelling evidence points to metabolic dysfunction arising at the level of fat cells (adipocytes), which become overdistended. How did these adipocytes get so full? Excess dietary linoleic acid.
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metabolic dysfunction is driven by overly distended adipocytes and that is related to excess linoleic acid
you could have underlying metabolic dysfunction in my opinion from excess linoleic acid causing the adipocytes to overextend over expand and if you don't correct that you're never going to get well