Peter Attia· MD
there's clearly a subset of people I think my n is too small to quantify it but directionally it seems like I don't know ten or twenty percent of people when you put them on ketogenic diets in the standard way which usually ends up meaning you're getting at least forty percent of your calories from saturated fat typically 40 to 45 percent from mono and the remainder from Holley everything goes to hell in a handbasket and the obvious things that go to hell in a handbasket have been certainly written about on the blogosphere and Twittersphere which is usually their LDL particle numbers skyrockets despite the fact that their triglycerides go down so they seem to be getting more insulin sensitive but yet inflammation is going up and you see that both specifically cardiac specifically so things like oxidized LDL and LP PLA - but even non specifically C reactive protein fiber engine but the deeper level is the Y and what you see is they're making much more cholesterol markers of cholesterol biosynthesis like des Marshall all go way up and some of their phytosterols go up which is very counterintuitive