Excess fructose from high-fructose corn syrup can be problematic due to overconsumption, but fructose from whole fruits is unlikely to cause issues for most people.

“excess fructose in the setting of high fructose corn syrup sure you could over consume it we know that over consuming anything is going to be a problem for humans if you get massive amounts of excess calories that's going to be problematic because of the differences in fructose and glucose metabolism problem but if you're eating fruit that's not going to cause problems for most humans”