Prostate growth may be influenced by a hormonal balance of a lower testosterone to estrogen ratio, especially in aging men with metabolic syndrome.

“so as men age their prostates grow and I believe that that's more hormonal so in other words if you're saying that you know again classic thinking that has clearly been proved false is that testosterone is causing prostate cancer you're saying it's way more Nuance than that and it's maybe if the endocrine component of prostate cancer may be more related to the relationship of testosterone and estrogen yes and a declining testosterone in the presence of a rising estrogen would be a more favorable endocrine milu for prostate cancer than the younger phenotype Which is higher testosterone to estrogen”