Peter Attia· MD
they become very fat they become insulin resistant they they develop all features of metabolic syndrome and when we look in their livers they're making fructose and they've turned on this enzyme this polyol pathway is high
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
they become very fat they become insulin resistant they they develop all features of metabolic syndrome and when we look in their livers they're making fructose and they've turned on this enzyme this polyol pathway is high
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the third mechanism is this polyol pathway also gets turned on over time and so what happened and and like by the time you have metabolic syndrome you probably have this enzyme turned on um because you're you're have a high uric acid and as i mentioned that that can can activate this pathway too