Animals with a fructokinase knockout gain less weight than normal animals when given glucose alone.

“if we knock out fructokinase just in the liver we can protect animals from obesity and diabetes and high blood pressure”

“these animals do not uh develop insulin resistance they do not develop fatty liver they do not you know they're really protected from the metabolic syndrome and they and they gain much less weight and have less fat than a normal animal”

“what happens is these animals do not uh develop insulin resistance they do not develop fatty liver they do not you know they're really protected from the metabolic syndrome and they and they gain much less weight and have less fat than”

“but um but most of the fructose you know it gets ends up getting metabolized in the liver and the liver seems to be the primary place that drives the metabolic syndrome and obesity and diabetes and if we knock out fructokinase just in the liver we can protect animals from obesity and diabetes and high blood pressure”

“uh i have a small company we're trying to develop fructokinase inhibitors uh for the treatment of metabolic syndrome and uh and other uh conditions associated with fructose but there are also several large pharma that are actively uh working on making fructokinase inhibitors and eli lilly for example is one that's actively trying to make fructokinase inhibitors”

“what happens is it continues to keep its ciao low so even though it's eating drinking a lot of glucose the the chow stays low so that the overall energy intake is only very”

“the amount a mouse that just gets glucose alone really gains weight a mouse that gets glucose in which they cannot metabolize fructose it's dramatically less but it's still a little bit more than normal”