Peter Attia· MD
so the fructokinase knockout tends not to want to eat sugar they tend not to not like fructose and so you have to kind of force them to eat the fructose but even if you force them to eat the fructose they'll never get fat uh the v1b receptor knockout like fructose they'll eat as a lot of sugar but they'll they won't get fat so what how are they disposing of their fructose they're totally regulating uh their caloric total caloric intake so although they eat more fructose they'll eat less chow so they maintain their energy balance right but how do they not turn into skinny fat mice who are lean because their overall energy balance is fine but they still get fatty liver disease and they still get diabetes they do not get that they don't they don't get fatty liver they don't get insulin resistant they stay normal but that's counterintuitive right because you'd think that the remember the energy restricted high fructose animals were still getting they were lean but they were inside fat right they had visceral fat they had liver fat they had hypertension so remember that the metabolic syndrome was driven through the energy depletion pathway and and and the uh the actual caloric pathway is still intact so what what's happening with this is that the um well what we know is that it's down regulating fructokinase this is probably the key key point the v1b receptor knockout have less they don't they don't have as much fructokinase they're turning it off they're reducing the amount uh normally when you eat sugar you um the fructokinase levels get higher and higher they get turned on by sugar and the v1b knockout doesn't do that so the fructokinase stays at a low level