Normal glucose disposal into a cell involves insulin binding to its receptor, signaling through IRS1 and PI3K, promoting GLUT4 translocation to the cell surface for passive glucose entry.

“when the insulin molecule hits the insulin receptor on the surface i believe it auto phosphorylates itself correct that then signals to insulin receptor substrate one irs one inside the cell so that sends a signal inside the cell which also leads to a phosphorylation which then signals pi3 kinase it up regulates pi3 kinase and that basically leads to a glute4 transporter which you can think of as like a big tube being shoved up to the surface of the cell across its membrane and that basically passively allows glucose in it is not an active transporter correct”