Disruption of circadian clocks leads to inefficient metabolism, accumulation of byproducts, cellular stress, and ultimately disease.

“So the master clock sends the signal that when it should be day, when we should be eating, when we should be fasting, and accordingly, the liver clock, the gut clock, all these clocks that time themselves...So these clocks actually have timed different things, and when clocks break down, then what happens is you can imagine there are traffic jam and a big pile-up. So the metabolites, metabolism is not efficient anymore. There is a lot of byproducts just lying around and that stresses the cell and then we get to the disease.”

“And we believe that when those two clocks are out of sync that that itself leads to some type of metabolic dysregulation.”