Disturbed metabolism can lead to the production of reactive oxygen species or free radicals, which can cause mutations, with metabolic disturbance being the primary event in some advanced cancers.

“and not only that metabolism can go wrong and sometimes as shown by whole genome sequencing of over 2000 tumors that there are a few cancers where no mutations were found in advanced cancers so how did that happen well because sometimes it is the disturbed metabolism that then leads to production of reduced oxygen species or free radicals for example that go and chop up and cause mutations and that genetic mutations are a secondary event the primary event is a metabolic disturbance”