We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
inhibition happens at millimolar concentrations and clinically not relevant our concentrations of metformin in humans metformin are about 50 micromolar 40 to 50 micromolar not millimolars which is what inhibits complex one and i think it's downstream it does affect the mitochondria does lead to the redox but it's not through the complex one
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
i want to challenge you on that we can talk about that but to me it's complex one inhibition happens at millimolar concentrations and clinically not relevant our concentrations of metformin in humans metformin are about 50 micromolar 40 to 50 micromolar not millimolars which is what inhibits complex one and i think it's downstream it does affect the mitochondria does lead to the redox but it's not through the complex one it's probably indirectly inhibiting mitochondrial glycerol phosphate dehydrogenase that's what leads to the redox but we can come back to