Metformin can exert epigenetic effects, such as histone deacetylation, independent of mitochondrial function.

“now metformin binds to Complex I in mitochondria I'll tell you that metformin has some action epigenetic action that are independent of the mitochondria you can do it with what's called row zero cells you can you can deplete mitochondria and see and measure things and you can measure things even without mitochondria okay again do I need them what type of epigenetic changes you see in the row cell in histone deacetylation okay so I cannot argue that this can be important it's not important if we use metformin but it's important if you want to ask me are the mechanism of it forming a MP dependent mitochondria ATP dependent so there's an H Dec property that we may not have even thought of before right”