Peter Attia· MD
metformin is decreasing mdor and exercising increasing mtor so all the emptor transcripts were higher in the exercise only group and were blunted by metformin and were these elderly or young 75 years old 75 yeah all elderly because there's other papers where emptor inhibitors don't decrease muscle mass in older people so that's you know it doesn't seem to just a minute let me just tell you the main result 516 of the transcript were different between them they were only in the metformin group and those were the transcripts that we want to see with aging such as transcripts for autophagy so basically what i'm saying in this elderly population what the metformin did is kept the young profile of the muscle and at the end yeah maybe you had less muscle but the same function but you gained by metformin protecting 500 transcripts that are aging transcripts