The TAME trial's primary outcome is a composite score including mortality, major adverse cardiac events, cancer occurrence, and mild cognitive impairment or dementia.

“it's the cluster of bunch of cardiovascular cancer cognitive and mortality it's the cluster”

“why is mortality given equal weighting to disease occurrence is there a reason that mortality wouldn't be three points to one point for mci mace and cancer well it was question for each one of them uh and we decided just that uh that we we cannot rationalize that everyone is an outcome”

“so you get one point if you die right for everyone you get one point if you have a major adverse cardiac event right one point if you have a cancer occurrence exactly skin cancer right and and mci or dementia got it”