The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
they were talking about what is the trial that we want to do and I think there is a lot of debate and healthy conversation around whether they should use metformin or rapamycin and I wish that there was enough resources in the world to try both but it sounded like they had to do one then it was metformin
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and i think combining metformin and rapamycin is like just i mean the rapamycin part is the one that we want to be careful with but on theory look that's where it's going let's say tame ends okay and let's say the fda agrees that aging can be prevented age-related disease can be prevented and everybody can take metformin because it's so cheap i think the next stage is combination of drugs better drugs timeline you know different timeline when is the best time to start rapamycin when is the best time to start metformin synolitics we don't want to start when you're 20 years old there's nothing obstinacies right so there'll be a lot of calculations so i'm not against that
It's a standard things and so so do you think metformin will have um geroprotective properties in people who are metabolically healthy skeptical but I think what it is saying is that if you catch preconditions early enough you keep you you protect against the other failure states a a little bit too.
metformin failed. Yeah it failed but it it it's it seems to be having very powerful effect in terms of um um well it did not fail actually it failed unless it was paired with rapamy.