Peter Attia· MD
the metformin study in males in one center they lived ten percent longer in one also ten one was nine one was eleven or something like that in one center it was one percent less okay so you know it's not significant
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the metformin study in males in one center they lived ten percent longer in one also ten one was nine one was eleven or something like that in one center it was one percent less okay so you know it's not significant
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are you saying it's possible there were methodologic errors in the third site that again if you had done it across 50 sites which as a purpose of a thought experiment it might have shown a benefit but three sites if one goes wrong i want to make a bigger comment maybe yes i want to make a bigger comment it's a little bit too late to discuss my style right because we have all those data in humans i think we have to be careful with the itp because it's possible that for example in humans metformin will have better effects than in mice rapamycin might have less effect in mice
metformin was successful in the itp where metformin was successful in the itp when combined with rapamycin but alone was not
so the other point is which which i think i'm trying to get to the bottom of that but when you gave metformin to animals in the itp in two centers they had 10 you know one was 11 and one was nine percent increase in longevity but rich miller's er er er point was minus two percent and and i i i just wonder if they're all actually delivering the same dose and and what's going on
metformin I think has been very sensibly proposed as a potential anti-aging drug in people I I don't know enough about its benefits and side effects I know that you yourself have you know 10 times more information about this than I do but a case has been made because it's so very safe uh in people that it could be used in people to postpone aspects of Aging I can see reasons not to believe that but at least you can make a case for that it doesn't seem to work in mice um the ITP showed that it didn't work in mice and now several other groups have conf confirmed that result Rafa diabo at one point claimed that it worked in mice but he used a very weird statistical test and I suspect that if you had if he had used the standard statistical test it would have failed in his lab as well I haven't seen the data so I'm not sure of that but that's my guess