Peter Attia· MD
we haven't done this study we don't know if it's safe as it is in young people and so we don't have really a clinical study with evidence that this is good
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Direct evidence is thin. The claim is plausible and aligns with adjacent findings, but there isn't yet a body of high-quality work that would let us call it well-supported on its own terms.
we haven't done this study we don't know if it's safe as it is in young people and so we don't have really a clinical study with evidence that this is good
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what I think is not entirely clear and I think is the purpose of what NIR is hoping to study with tame is if you took a non diabetic non insulin resistant individual and gave them metformin will you enhance their longevity phenotype
what if the benefits of metformin are only going to be most pronounced in people who have otherwise quite defective mitochondria to begin with and/or people who can tolerate a slight hit in the sort of mitochondrial performance because of all the other benefits they're getting and what if that doesn't hold true for someone who's otherwise quite healthy and looking to really maximize mitochondrial health and throughput
Do you think that in a healthy individual who's eating well is of normal weight is insulin sensitive and is exercising robustly metformin could actually be counteractive to benefit that's a profound question i don't know the answer to that and it gets into i don't know if you're going to take me there in terms of the use of metformin for aging healthy people are taking it for ag now i think that's why it's so important to understand this mechanism and then understand the implications of it it is redox is that a good thing or not for longevity and health that's a question that remains to be answered
it sounds like you're equally kind of undecided on that as well yes well jerry i can't thank you enough again i say this to many people i interview but i really mean it here it's not just for this discussion and the time you put into it but obviously much more importantly for the career and for this incredible body of work that you've amassed through your pursuit and obviously remarkable collaborations with so many people i've enjoyed this discussion immensely that's actually one of the discussions i'm gonna have to probably go back and listen to again so i hope that a listener isn't hearing this and isn't discouraged by the fact that you're at this point in the discussion and you're thinking oh my god i might have only retained half of that that's okay i'm gonna be listening to this one and i just finished listening to it now and i'm going to listen to it again so thank you very much jerry for that thank you peter it's been a pleasure thank you for listening to this week's episode of the drive if you're interested in diving deeper into any topics we discuss we've created a membership program that allows us to bring you more in-depth exclusive content without relying on paid ads it's our goal to ensure members get back much more than the price of the subscription to that end membership benefits include a bunch of things one totally kick-ass comprehensive podcast show notes that detail every topic paper person thing we discuss on each episode the word on the street is nobody's show notes rival these monthly ama episodes or ask me anything episodes hearing these episodes completely access to our private podcast feed that allows you to hear everything without having to listen to spiels like this the qualis which are a super short podcast that we release every tuesday through friday highlighting the best questions topics and tactics discussed on previous episodes of the drive this is a great way to catch up on previous episodes without having to go back and necessarily listen to everyone steep discounts on products that i believe in but for which i'm not getting paid to endorse and a whole bunch of other benefits that we continue to trickle in as time goes on if you want to learn more and access these member-only benefits you can head over to petertiamd.com forward slash subscribe you can find me on twitter instagram and facebook all with the id peteratiammd you can also leave us a review on apple podcast or whatever podcast player you listen on this podcast is for general informational purposes only does not constitute the practice of medicine nursing or other professional health care services including the giving of medical advice no doctor patient relationship is formed the use of this information and the materials linked to this podcast is at the user's own risk the content on this podcast is not intended to be a substitute for professional medical advice diagnosis or treatment users should not disregard or delay in obtaining medical advice from any medical condition they have and they should seek the assistance of their health care professionals for any such conditions finally i take conflicts of interest very seriously for all of my disclosures and the companies i invest in or advise please visit petertiamd.com forward slash about where i keep an up-to-date and active list of such companies [Music]