Peter Attia· MD
so the point was you need to use drugs in combination so we said we're going to use what what we think are the best drugs at the time so we started with metformin with exenatide an old time gp1 this is not the Kingpin this is the pre- glutide yeah exactly because that's what was available that drug was useless wasn't it no it's a good drug sure it's not semaglutide but you have to start somewhere yeah let's let's pay it its dues as being the Gen one OG version of that drug without which we might not have we wouldn't have semaglutide or tepati yes so it's kind of an Oldtimer in pitone that was the triple therapy okay uh and then we said every diabetic patient there 315 people in this study they're having insulin clamps hypoglycemic clamps muscle bibes no one in the world can do this study 315 people follow for six years okay so we said this is what we believe is the appropriate therapy and then we said we'll use the Ada approach the Ada approach is you start a metformin okay and when you fail even though explicitly said the next drug that's used is self Fallas and then the third drug that's added is insulin and we said uh that the goal of therapy was an A1C of 6 and a half 6 years later okay 29% of the people with the Ada approach have failed their A1C is above six and a half six years later with our approach 70% of the people have an A1C that's less than six and a half why insulin clamp huge improvement with our therapy okay this is the eting study the the three-year data published the six-year data we're writing it up