The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
you do if you go to certain doses it's not physiologically we can't do we owe the anti-diabetic dosing that is given to people I mean there's some toxicity can happen due to certain patient populations and that's but it's a very safe drug
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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i don't think it's really disputed that metformin inhibits complex one is it i think the broader question is how much is that the main attraction versus kind of a sideshow right yeah i i'll say you know there are many people who know more about this than me but one thing that we tend to do in our lab sometimes take these kind of famous metabolic effects like metformin inhibiting complex one and just do a quick test of it and i say when we do that about half the time they look to be true and half the time they look to be dubious and metformin was a shining star in our hands in inhibiting complex one it was one of the cases where i really felt like you know it may do other things but it certainly does what it's supposed to do there it does that strongly and i think it's probably the fact that it does it in a relatively liver specific way due to the way that metformin enter cells of the body that leads to it first of all being safe