Peter Attia· MD
you could reduce glucose and of course metformin falls into the latter category of that or increasing muscle insulin sensitivity for to enhance glucose disposal today it's generally regarded that while both strategies will have an equal benefit on the microvasculature the glucose lowering by insulin lowering so the less glucose production strategy has a superior effect on the macro vasculature and therefore metformin would be a better alternative to for example a drug that's going to increase insulin production under the pancreas