There is no clear dose equivalence established between metformin and rapamycin/rapalogs for achieving equivalent mTOR inhibition.

“do we have a dose equivalence because what you just said for the listener i want to make sure is is clear metformin is a weak mitochondrial toxin it inhibits complex one that tricks the body basically into doing something which is thinking nutrients are scarce amp kinase goes up it thinks there's a deficiency of energy we know that that has a downstream effect on the inhibition of mtor something that we're going to talk about happening directly through the rapamycin rapilog pathway but what i'm trying to understand is using the cellular assays where we can read out the extent of that inhibition do we know that five milligrams of rapamycin or everolimus is equivalent to a thousand milligrams of metformin in other words do we have a sense of what an apples to apples mtor inhibition looks like even though one's direct and one is is indirect”