Metformin's geroprotective effects in non-diabetics may involve fundamental mechanisms beyond glucose homeostasis regulation.

“i don't believe for a second that metformin independently targets all of them and i think that's what we should note metformin let's say on the cellular level it fixes aging okay once it fixes aging a lot of things improve okay maybe the fact that insulin levels go down doesn't have to do only with metformin effect on glucose but because autophagy has increased mitochondrial function is better genetic stability is good you know things like that”

“so metformin we're going to talk about today less because of its diabetic effects we're going to talk about it through its zero protective effects”

“the last time I had near on the podcast his rationale for why Matt foran was geroprotective had nothing to do with glucose homeostasis and a non-diabetic it was and I know you're going to love this I mean Rich you're really going to love this there was a figure of the Hallmarks of aging and how met Foreman on each of them sure which which is I mean but my point being not not not to say that that's incorrect correct or anything it's that that there was something much more um Primal about met foran's actions”