Direct evidence is thin. The claim is plausible and aligns with adjacent findings, but there isn't yet a body of high-quality work that would let us call it well-supported on its own terms.
of course the question is what is the benefit of metformin in a perfectly healthy person or even a fully optimized person with respect to other variables i'm not aware that there is a benefit of it remember it has some adverse effects on mitochondrial function too potentially
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the question really arises around the use of metformin and whether or not there's sort of a true impairment of mitochondrial function or whether the elevated lactate levels we see in patients taking metformin is an artifact of the drug itself but says nothing of the mitochondrial function do you have any more insight into this question
is it does it really mess up with the whole M CLE function or can even like the M kind function overall override that inhibition of complex one and and override other Pathways I I don't think we know the answer to that
i don't think i know i mean i think having more circulating lactate can be you know a bit of a challenge for clearing fat right because they have some sort of competition so from that perspective i think you know being in a a lower state might have some benefits but then you know lactate is a valuable fuel as long as it's not getting to too high levels so i i'm not sure how that all plays out in terms of long-term health