Combining metformin with rapalogs may increase side effects, and the benefits must outweigh the risks, especially in patients with cancer where autophagy enhancement is undesirable. — Whalespan
Combining metformin with rapalogs may increase side effects, and the benefits must outweigh the risks, especially in patients with cancer where autophagy enhancement is undesirable.
⚠ High risk
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
◐PARTIALLYSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“i do think tanir's point every drug that has a biologic effect has a side effect and so if you use two drugs that have a biologic effect you're just going to get more side effects so you got to make sure that the benefits outweighing the risks let me give you an example if both of them are enhancing autophagy okay which is good and it's synergistic but the patient has cancer then it's when we want to stop autophagy”