A combination of metformin and canagliflozin reduced hemoglobin A1c by 1.8%.

“and interestingly when a second trial was done that looked at metformin plus canaga flows in it found an average reduction in the hemoglobin A1c of 1.8 percent that's really significant right so somebody shows up at 7.8 percent hemoglobin A1c so they're clearly and well into the territory of type 2 diabetes where the threshold is 6.5 percent and that person is going to come down to 6.0 so they're going to go from being you know in a state of raging type 2 diabetes to being pre-diabetic”