Peter Attia· MD
metformin doesn't hit mTOR does though ampk does the ampk but that's due to first hitting mitochondrial complex one and then activating ampk which can repress mTOR
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
metformin doesn't hit mTOR does though ampk does the ampk but that's due to first hitting mitochondrial complex one and then activating ampk which can repress mTOR
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and I would tell you the downstream of am P kinase there is mTOR okay and it depletes a decrease mTOR activity and increase autophagy
metformin annamaria cuervo is using MIT formulas the control for a tougher G okay it activates a tough OG really well okay so that's it I'm talking about in vitro assays
we know that that has a downstream effect on the inhibition of mtor