there are several the good studies all showed that people of metformin have less alzheimer's there are some studies that don't show that and there are two reasons for that or possible explanation one they're from china okay either it's not similar mechanisms genetics and environmental interaction somehow you know possibly but more likely is that think about this this way you you really have to do it good because if metformin delays mortality by 20 okay that means you'll get more people on metformin lingering longer right and it might be just that effect that all of a sudden the people with alzheimer are hanging around longer so those studies it's kind of why we need clinical studies and not associate studies absolutely because they're so co-dependent dependency of things that we're looking at