Metformin's major mechanisms of action include targeting mitochondrial complex I, increasing AMPK, and inhibiting mTOR.

“so big pillar one is the metabolic complex one ampk mtor pathway right which is what we just discussed the second is there is a decrease in oxidative stress in rose production and therefore also on dm dna damage that is the consequence of using a low dose of a mitochondrial poison right so there's this aspect of that and the third aspect the relationship to autoin to immune function and inflammation so those are kind of the i think the major effects on metformin”