Metformin requires an organic anion transporter to enter cells, and muscles lack this transporter, suggesting metformin does not significantly enter muscle tissue.

“you never see it in the muscle okay and that's even more graphic demonstration you know uh that metformin is not getting into muscle and it is definitely not an insulin sensitizer”

“absolutely not a single molecule in the world of metform has ever gotten into any skeletal muscle anywhere and tell me again why what's the transporter the organic cation transporter that's the transporter that uh by which metformin enter cells it does not exist in skeletal muscle it does not exist in cardiac muscle so metformin cannot get into these tissues”

“metformin gets into cells through the organic cation transporter the organic cat iron transporter doesn't exist in muscle it can't possibly be an insulin sensitizer in muscle you're asking the drug to do something that's impossible”