Metformin's primary mechanism of action is liver-focused, unlike sulfonylureas or TZCDs.

“my study was the first to show that metformin specifically targets a hepatic glucose production rather than or or let's say the insulin sensitivity of the liver rather than the muscle although it's doing a little bit of both”

“Metformin really acts primarily to reduce glucose production so it's uh it's going to reduce what's called hepatic glucose output maybe it increases glucose utilization in the muscles I think that's far less of an effect”