Chronic stimulation of mitochondrial oxidative stress, particularly from fructose, decreases the number and efficiency of mitochondria, resulting in reduced ATP production and fatigue.

“but what happens is um if you keep stimulating mitochondrial oxidative stress and it's been shown with fructose for example the mitochondria start to decrease and um and the mitochondrial change they become smaller and less efficient and what happens is the mitochondrial function starts to to to to reduce a number and and so you have less mitochondria and when that happens you can you make less atp so you'll fee it's associated with feeling more fatigue more tired if you have lower atp levels in your muscle it's associated with muscle fatigue your natural gait will slow down as your mitochondrial function decreases and it's all associated with aging”