Excess ketones can competitively block glucose metabolism at the Krebs cycle entry point, leading to increased intracellular glucose metabolites that may form advanced glycation end products.

“excess of ketones competitively blocks the metabolites of glucose entering the kreb cycle under these conditions glucose is freely transported into the cell but the pathway of metabolism is effectively blocked at the entry point to the kreb cycle so that's to mitochondrial respiration by the ex ESS of metabolites arising from fat and protein breakdown as a result of this competitive block at the entry point to the crep cycle intracellular glucose metabolites increase damning back through the glycolytic pathway and that also is where you see that that damning into the polyol pathway with the production of intracellular glucose and then possibly age for the advanced glycation end products leading to accumulation of free intracellular glucose and inhibiting initial glucose phosphorilation as a result much of the free intracellular glucose transport into the cell is transported back out of the cell and into extracellular fluid thus under conditions of Keto acidosis glucose metabolism but not glucose uptake is impaired as a direct consequence of the metabolism of fat the glucose fatty acid cycle and then they cite Randle”