Mitochondrial dysfunction can lead to excess, unutilized oxygen, contributing to pathology in rare diseases.

“one of the consequences of mitochondrial dysfunction is excess unused oxygen so in other words if a mitochondrion is failing to do its job you will be failing to utilize oxygen therefore you would see an excess accumulation of oxygen that's right and we believe this is our hypothesis now it's that some of that excess unused oxygen is what is contributing to the pathology that we see in some of these rare diseases”