Paul Saladino· MD
the nadh offloads its electrons onto like the first on-ramp it's like a bus it's a certain bus yeah and it gets off at the first one which is called complex one exactly and then fadh2 fadh2 drops off its uh its electron cargo off um feeds it into the system at the second on-ramp um uh what is it succinate complex two we'll call it succinate dehydrogenase i think but complex two and so which is associated with a coenzyme q10 coenzyme q and so both complex one and complex two feed their electrons next to this coenzyme q and so the problem is um you've got two you've got two on-ramps but they both have to go through this same coenzyme q and so you've got a bottleneck situation where if if every if all of the electrons are entering the thing through complex one if they're all on nadh and they're going into complex one um the electrons flow straight through there's no problems there's no bottlenecks no uh reactive oxygen species are generated but the more that you feed things in through the second on-ramp and everything's got to get through coenzyme q now you start to get you get this bottleneck effect and there's just simply too many electrons for coenzyme q to carry and when that happens some of those electrons um ping back out of the system they do what's called reverse electron transport