Mechanotransduction, chemical stimuli from mechanical cell movement, signals cells to be healthy, while lack of movement signals sickness.

“there's a fancy term called Meccano transduction which is the chemical stimuli that manifests is a product of that that chemical or mechanical movement of a cell you know so as when you go through and twist and turn all those cells there's that's information now your cells are hearing you and so when you don't move those cells they say oh maybe we're sick okay I hear you I think you're sick movie there must be a problem yeah exactly are you sitting down so much you must be sent you must be sad because no or maybe depressed right we're defensive or injured yeah because at no point in our evolution in the last three million years of human evolution have we sat that much”