Insulin resistance is primarily caused by mitochondrial dysfunction triggered by stress hormones, gut dysbiosis, endotoxemia, polyunsaturated fats, and nutrient deficiencies.

“so I think that there's M like a multifold problem going on that kind of spins out of control and so what I think is going on is you get some type of metabolic dysfunction at the mitochondrial level and that could be stress hormones over the long term can cause that gut dysbiosis and endotoxemia and things like this can cause that I think long-term consumption of polyunsaturated fats and incorporation into mitochondrial structure can start to cause problems as well nutrient deficiencies yeah react heavy amounts of reactive oxygen species production from nutrient deficiencies or exposure to different components can start to cause that”