Preventing fever for 24 to 72 hours after a brain injury is critical because fever increases the mismatch between metabolic rate and energy production, exacerbating the injury.

“a period of 24 to 72 hours after the initial injury is probably the most critical um the the most important thing is preventing fever and the reason why the reason why fever causes issues is because you cre you increase the mismatch between metabolic rate and capacity to produce energy to match that metabolism so if you have mitochondrial dysfunction you're basically increasing that Gap in terms of required energy production which then um exacerbates the injury”