Astrocytes in the brain, which are primarily glycolytic, continually produce lactate that is shuttled to neurons for use as an energy source.

“I mean you probably know more about its role in neurons which I think is just starting to become appreciated we've typically thought of neurons as only accepting glucose and ketones but I think there's emerging evidence that lactate is a fuel and then of course the liver can turn lactate right back into glucose via the Corey cycle”

“Lactate is continually made by astrocytes in the brain which are primarily glycolytic. This lactate is shuttled to neurons and used as an energy source.”

“Neurons are actually mostly using lactate from astrocytes. Astrocytes are glycolytic. The astrocytes are these brain cells in your brain which are using glucose mostly, or using glucose to generate lactate.”

“asites in the brain which are a supporting cell for neurons they're mostly glycolytic that means they're mostly using glucose as energy they're not using mitochondria and they're producing lactate as a byproduct so asites are turning out tons of lactate in the brain and that lactate is be being taken up you know by neurons through the the MCT Transporters and used as energy”