The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
sirtuins are fundamentally different in that they they use up nad right uh um uh and so nad is required for their activity nadh the reduced form of nad is actually an inhibitor of sirtuins so the nad to nadh ratio can be used as a proxy of of likely sirtuin activity
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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sirtuins are a class of nad dependent mostly deacetylases they also can do some other activities but basically one way to think about it is that that sirtuins uh take acetyl groups off of other proteins that's their activity and that that requires nad and it actually consumes nad
nadh the reduced form of nad is actually an inhibitor of sirtuins so the nad to nadh ratio can be used as a proxy of of likely sirtuin activity