Exogenous nicotine supplementation is likely not a net positive due to potential negative downstream effects, despite nicotine occurring naturally in the body and having some positive brain effects.

“Um, and I think that there may be some studies that suggest that it affects the brain in a positive way, but there's always other side effects, right? So when you introduce exogenous nicotine, when you introduce excess nicotine akin to what happens with marijuana because canabonoids occur naturally in the human body, there are other downstream effects in the human body. And I think that to say that nicotine supplementation or these pouches is net positive, that's a stretch.”