The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
in mitochondrial disease you see the same shift it's just much much more pronounced you see a shift towards nadh and less nad and that's exactly what you see when mitochondria are less functional because the cells will switch over to glycolysis and fermentation right fermentation to lactate and the whole reason why we ferment to lactate is to restore nad levels right fermentation to lactate takes nadh and turns it back into nad
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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in mitochondrial disease you see the same shift it's just much much more pronounced you see a shift towards nadh and less nad
So we like we discovered in in in collaboration with University of of Helsinki a number of years ago that people with mitochondrial disease that were thought to primarily have muscle mitochondrial myopathy right are walking around with low blood NAD.