Paul Saladino· MD
our bodies are actually destroying nad through tarps and sirtuins and then they're recycling it back from nicotinamide all the time it's called the nad salvage pathway
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
our bodies are actually destroying nad through tarps and sirtuins and then they're recycling it back from nicotinamide all the time it's called the nad salvage pathway
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And there's a specific inhibitor of this enzyme called NMPT you can add it to cells we've done the experiment within four to six hours NAD levels down to zero the cell dies so there's an incredible churning through that whole pathway now which is a reflection of the activity of suins uh CD38 CD 157 the PARPs and so on
Nicotinomide is a precursor to NAD and so this nicotenomide which is generated by CD38 but by the sertuins by the PARPS normally gets recycled um in a two-step reaction all the way back to NAD. Now what's really interesting is if you block this it's called the salvage pathway for nicotinomide. If you block it within a few hours your NAD levels go down to zero. So the system Wow. heavily dependent on recycling.