NAD supplementation can protect against noise-induced hearing loss in mice.

“So, for example, the paper we’ve published was focused on the age-associated or noise-induced loss of hearing. So, if you actually subject mice or humans to very acute noise, they have a dose-dependent loss of hearing. You can protect the mice completely from this effect by supplementing with NAD. But with nicotinamide riboside, so if you’re going to a rock concert… Yes. In mice, it actually had an enormous effect, and we found that this effect was dependent on sirtuin-3, so in sirtuin-3 knockout mice, the effect was lost.”