Subsequent studies with longer-lived controls did not replicate Johan A's lab findings that NAD+ boosting increased lifespan.

“for lifespan the original study by Johan A's lab where they started treating I think at 20 months of age was published in science I believe um showed an effect that was reasonably good sized except the controls were short which is a different issue yeah it's a different issue right you see a lot of there there a a number of cases where something was reported to increase lifespan when the controls were shortlived and then when when the study was repeated and longer lived controls you didn't see an effect”